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October 1973

Chlorpromazine Treatment of Disturbed Monkeys

Author Affiliations

Madison, Wis; Nashville, Tenn
From the Department of Psychiatry and Primate Laboratory (Dr. McKinney), the Department of Psychiatry (Dr. Young), the University of Wisconsin School of Medicine, Madison; the Department of Psychology, the University of Wisconsin, Madison (S. Suomi); and the Department of Psychiatry and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn.

Arch Gen Psychiatry. 1973;29(4):490-494. doi:10.1001/archpsyc.1973.04200040042007

Four rhesus monkeys which were subjected to partial social isolation during the first 11 months of life and which had consistently exhibited patterns of grossly abnormal behavior during the 1½ years prior to the current study were treated with chlorpromazine.

Three of the four subjects showed significant decreases in their self-disturbance behaviors on 7.5 mg/day of chlorpromazine given as the liquid concentrate by nasogastric intubation. The fourth subject showed no change. Plasma chlorpromazine levels confirmed absorption of the drug in all subjects.