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February 1974

Premorbid Functioning and Outcome in Schizophrenics and Nonschizophrenics

Author Affiliations

Palo Alto, Calif; Chicago; New Haven, Conn
From the Social Ecology Laboratory, Department of Psychiatry, Stanford University School of Medicine (Dr. Bromet); PPI, Michael Reese Hospital, and the Department of Psychiatry, University of Chicago (Dr. Harrow); and the Department of Epidemiology and Public Health, Yale University School of Medicine (Dr. Kasl).

Arch Gen Psychiatry. 1974;30(2):203-207. doi:10.1001/archpsyc.1974.01760080061010

The relationship between premorbid and morbid factors relevant to the process-reactive distinction in schizophrenia and measures of posthospital adjustment were investigated in 33 schizophrenic and 44 nonschizophrenic patients.

The data support the hypothesis that these premorbid and morbid factors are predictive of outcome for schizophrenics, although the correlations between the predictors and outcome indexes were not as uniformly high as theories based on the process-reactive distinction have proposed.

For the nonschizophrenics the correlations between the predictors and outcome indexes did not show consistent associations. The premorbid factors employed were differentially related to the various outcome measures. The results provide some support for the hypothesis that different factors predict outcome for schizophrenic vs nonschizophrenic patients, and question the hypothesis that all mental illnesses form a continuum with the difference between them primarily being one of severity.