Sixty-two children from economically deprived urban areas and diagnosed "hyperkinetic reaction of childhood" were studied in order to evaluate the effects of methylphenidate hydrochloride in this population.
Methylphenidate was as effective in this population as it has been reported to be in children from different socioeconomic and cultural settings. Improvement was noted in many areas of the child's functioning, and was observed by the parents, the teachers, and the treating physician.
Results of the study were further analyzed by dichotomizing the children according to the weekly variability in classroom hyperactivity over the 12-week treatment period. It was found that those children whose variability in weekly ratings of classroom hyperactivity was relatively high were seen as more of a problem by their parents at the base line evaluation than were the children whose treatment response tended to be less variable.
Stanley P. Hoffman, David M. Engelhardt, Reuben A. Margolis, Polizoes Polizos, Jonas Waizer. Response to Methylphenidate in Low Socioeconomic Hyperactive Children. Arch Gen Psychiatry. 1974;30(3):354–359. doi:10.1001/archpsyc.1974.01760090064011