The frequency of drowsiness attributed to orally administered chlorpromazine hydrochloride was compared among 130 nonsmokers and 201 "light" and 72 "heavy" cigarette smokers. Drowsiness occurred in 16%, 11%, and 3%, respectively. More rapid metabolism of chlorpromazine in cigarette smokers may explain these findings.
Swett C. Drowsiness Due to Chlorpromazine in Relation to Cigarette Smoking: A Report From the Boston Collaborative Drug Surveillance Program. Arch Gen Psychiatry. 1974;31(2):211–213. doi:10.1001/archpsyc.1974.01760140063010
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