The frequency of drowsiness attributed to orally administered chlorpromazine hydrochloride was compared among 130 nonsmokers and 201 "light" and 72 "heavy" cigarette smokers. Drowsiness occurred in 16%, 11%, and 3%, respectively. More rapid metabolism of chlorpromazine in cigarette smokers may explain these findings.
Swett C. Drowsiness Due to Chlorpromazine in Relation to Cigarette SmokingA Report From the Boston Collaborative Drug Surveillance Program. Arch Gen Psychiatry. 1974;31(2):211–213. doi:10.1001/archpsyc.1974.01760140063010
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