This report reviews conflicts in delineating the phenomena of depression with an emphasis on the central criterion role of the symptomatic pattern of the nonprecipitated (endogenous) depression. Depressions with similar symptomatology, regardless of precipitation or severity, are labeled endogenomorphic.
A specific causal model is presented that has testable consequences in drug treatment and maintenance studies. This is a mixed model, combining both categorical and dimensional constructs.
Klein DF. Endogenomorphic Depression: A Conceptual and Terminological Revision. Arch Gen Psychiatry. 1974;31(4):447–454. doi:10.1001/archpsyc.1974.01760160005001
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: