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November 1974

Drug and Sociotherapy in the Aftercare of Schizophrenic Patients: III. Adjustment of Nonrelapsed Patients

Author Affiliations

From the Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine (Mr. Hogarty); the Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Md (Drs. Goldberg and Schooler); and the Friends' Medical Science Research Center, Inc, Baltimore (the Collaborative Study Group).

Arch Gen Psychiatry. 1974;31(5):609-618. doi:10.1001/archpsyc.1974.01760170011002

We examined the effects of chlorpromazine and major role therapy (MRT) on the quality of community adjustment of schizophrenic patients during a two-year period following hospital discharge.

Among patients in the community, those treated with combined drug and sociotherapy adjust better than those taking the drug alone; to a greater extent, those receiving placebo alone adjust better than those receiving placebo and sociotherapy. However, only 20% of those in the placebo group have not relapsed after two years while the comparable percentage for the drug group is 52%.

Effects found on assessments made by psychiatrists, social workers, family ratings, and self-reports replicate at three clinics.

Maximum restorative benefits require both maintenance phenothiazine and psychologic treatment continued for beyond a single year following hospital discharge.

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