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November 1974

X Linkage Revisited: A Further Family Study of Manic-Depressive Illness

Author Affiliations

From the Department of Psychiatry, Dartmouth Medical School, Hanover, NH. Dr. Goetzl is now with the Department of Psychiatry, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.

Arch Gen Psychiatry. 1974;31(5):665-672. doi:10.1001/archpsyc.1974.01760170059010

We performed a family study of 39 individuals with proven manic-depressive disorder. Among the affected first-degree relatives of these probands, an overall parity of the male-female ratio was found. In addition, there were four instances of father-son transmission of affective illness involving probands of the sample.

These results suggest that any gene locus that exists on the X chromosome is not of itself a sufficient or necessary condition for the transmission of manic-depressive illness. Hence, any implication that X linkage is the primary mode of transmission in manic-depressive illness is premature.

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