[Skip to Content]
[Skip to Content Landing]
January 1975

Amine Precursors and Depression

Arch Gen Psychiatry. 1975;32(1):22-30. doi:10.1001/archpsyc.1975.01760190024002

The amino acid precursors, levodopa and L-tryptophan, were given to a group of hospitalized depressed patients in a double-blind placebo controlled study. Relatively large doses were not associated with sufficient clinical improvement to allow the patients to leave the hospital.

Previous studies using the precursor-load strategy have produced conflicting findings on the use of these compounds for depressed patients.