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February 1975

The Offspring of Schizophrenics: Fetal and Neonatal Deaths

Arch Gen Psychiatry. 1975;32(2):200-211. doi:10.1001/archpsyc.1975.01760200064006

This is the first report in a projected series on neurological development among the offspring of schizophrenics. An increased incidence of fetal and neonatal deaths is noted among offspring of schizophrenics when compared to a closely matched control group, using data collected prospectively.

In many cases, no apparent reason for death was determined; in some cases, major neurological malformations were found. It is necessary to consider three possible explanations for these findings—genotype of the child, adverse intrauterine environment, and medication toxicity.