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April 1976

Schizophrenia—A Follow-up Study of Results of Treatment: I. Design and Other Problems

Author Affiliations

From the Department of Program Evaluation, Research, and Education (Dr May) and the Statistical Research Unit (Dr Dixon), Veterans Administration Hospital, Brentwood, Calif; the Neuropsychiatric Institute (Dr May) and the Health Sciences Computing Facility (Dr Dixon), University of California at Los Angeles; and the Clinical Research Branch (Dr Tuma) of the National Institute of Mental Health, Rockville, Md.

Arch Gen Psychiatry. 1976;33(4):474-478. doi:10.1001/archpsyc.1976.01770040042008

• This is the first of a series of articles on a follow-up study of the results of treatment of schizophrenia, studied over a period of two to five years after first admission and first release. The study compares the follow-up outcome of five different treatment methods given to first-admission male and female schizophrenic patients in the hospital.

The design of the study is used as a basis for description and discussion of the practical, ethical, and statistical problems involved. A distinction is made between follow-up and continued treatment design, and it is concluded that both pose massive problems in execution, analysis, presentation, and interpretation.