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June 1976

Mother-Infant Separation in Rhesus Monkeys as a Model of Human Depression: A Recopnsideration

Author Affiliations

From the departments of psychiatry and psychology (Mr Lewis) and the Primate Research Laboratory, University of Wisconsin, Madison (Messrs Lewis and Kraemer and Dr McKinney), the Department of Psychiatry, Wisconsin Psychiatric Research Institute, Madison (Dr McKinney), and the Department of Psychiatry, Medical University of South Carolina, Charleston (Dr Young).

Arch Gen Psychiatry. 1976;33(6):699-705. doi:10.1001/archpsyc.1976.01770060035006

• Nineteen rhesus monkeys between the ages of 5.9 and 8.5 months were separated from their mothers in five different studies. While in two of the studies, data indicated behavioral responses roughly parallel to Bowlby's protest-despair response to maternal separations, data across all five studies were sufficiently variable to bring this technique into serious question as a reliable and predictable animal model for neurobiologic and rehabilitative studies.

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