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August 1976

Cardiovascular and Subjective Effects of Intravenous Cocaine Administration in Humans

Author Affiliations

From the departments of psychiatry (Drs Fischman, Schuster, Shick, and Freedman), pharmacological and physiological sciences (Dr Schuster), and medicine (Drs Resnekov, and Fennell), University of Chicago, Pritzker School of Medicine, and the National Institute on Drug Abuse (Dr Krasnegor), Rockville, Md.

Arch Gen Psychiatry. 1976;33(8):983-989. doi:10.1001/archpsyc.1976.01770080101010

• Nine volunteer subjects were tested with intravenously administered cocaine hydrochloride in doses ranging from 4 to 32 mg, as well as 10 mg of dextroamphetamine sulfate. Measures of cardiovascular and subjective effects were made. Generally parallel dose-effect functions were obtained for heart rate, blood pressure, Addiction Research Center Inventory scores, Profile of Mood Scales, and subject ratings. A substantial effect on each of these variables was recorded after 8 mg of cocaine. The increase continued and peaked at approximately 16 mg after which it usually leveled off. Ten milligrams of dextroamphetamine generally had an effect comparable to 8 to 16 mg of cocaine.

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