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January 1977

Fluphenazine Decanoate, Fluphenazine Hydrochloride Given Orally, and Placebo in Remitted Schizophrenics: I. Relapse Rates After One Year

Author Affiliations

From the Department of Psychiatry, Long Island Jewish-Hillside Medical Center, Glen Oaks, New York. Drs Rifkin and Klein are presently with the New York State Psychiatric Institute and The College of Physicians and Surgeons, Columbia University, New York. Drs Rifkin, Quitkin, and Klein are now with the New York State Psychiatric Institute, New York.

Arch Gen Psychiatry. 1977;34(1):43-47. doi:10.1001/archpsyc.1977.01770130045004

• In a sample of remitted, nonpsychotic schizophrenics, the relapse rate within one year was significantly higher for those patients taking placebo as opposed to those taking fluphenazine hydrochloride orally or fluphenazine decanoate. There were no differences in relapse rates between the two active drugs, but there were significantly more terminations due to toxicity from fluphenazine decanoate than from fluphenazine given orally, entirely due to the fact that in 35% of patients receiving fluphenazine decanoate, severe akinesia developed.