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August 1977

Extrapyramidal Side Effects in Chlorpromazine Recipients: Emergence According to Benztropine Prophylaxis

Author Affiliations

From the Drug Epidemiology Unit, Boston University Medical Center.

Arch Gen Psychiatry. 1977;34(8):942-943. doi:10.1001/archpsyc.1977.01770200080009

• The frequency of extrapyramidal symptoms (EPS) attributed to chlorpromazine among 86 patients who received benztropine for the prevention of EPS (9.3%) was similar to that of the 568 patients who received chlorpromazine alone (10.6%). The data in this small sample indicated that the prophylactic use of benztropine had no effect in reducing the rate of EPS.

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