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October 1977

A Neuroendocrine Study of Supersensitivity in Tardive Dyskinesia

Author Affiliations

From the Illinois State Psychiatric Institute (Drs Tamminga, Smith, Pandey, and Davis), the Division of Endocrinology and Metabolism, Michael Reese Hospital (Dr Frohman), and the Departments of Psychiatry (Drs Tamminga, Smith, and Davis) and Medicine (Dr Frohman), University of Chicago, Chicago. Dr Smith is now with the Texas Research Institute of Mental Sciences, Houston.

Arch Gen Psychiatry. 1977;34(10):1199-1203. doi:10.1001/archpsyc.1977.01770220081009

• A study of the tuberoinfundibular dopamine tract was undertaken in chronic schizophrenic patients with and without tardive dyskinesia. Biochemical evidence of the purported dopamine receptor supersensitivity in tardive dyskinesia was sought by demonstrating a hyperresponse of growth hormone and prolactin to dopamine agonists. Contrary to this prediction, no endocrine supersensitivity occurred in the tardive dyskinesia patients. Rather, a significantly decreased response to dopaminergic stimualtion was demonstrated in the total chronic schizophrenic group.

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