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August 1978

Chromosomes in Patients Receiving Methadone and Methadyl Acetate

Author Affiliations

From the VA Hospital Brentwood and the Department of Psychiatry, UCLA, Los Angeles. Dr Yen is now with the Child Evaluation Center, Department of Pediatrics, University of Louisville School of Medicine.

Arch Gen Psychiatry. 1978;35(8):989-991. doi:10.1001/archpsyc.1978.01770320083007

• Chromosomes of peripheral leukocytes were examined in 28 addicts participating in a Veterans Administration-Special Action Office for Drug Abuse Prevention (SAODAP) cooperative study of methadyl acetate vs methadone. Blood samples for 72-hour leukocyte cultures were drawn after nearly 40 weeks of maintenance therapy while subjects were receiving active medication. For comparison, ten nondrug users were also studied. The frequency of chromosome damage was not greater in subjects maintained on methadyl acetate or methadone than in nondrug users.