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August 1978

Peptides and Psychoneuroendocrinology: A Perspective

Author Affiliations

From the Department of Psychiatry, Biological Sciences Research Center, and the Neurobiology Program, University of North Carolina School of Medicine, Chapel Hill.

Arch Gen Psychiatry. 1978;35(8):999-1010. doi:10.1001/archpsyc.1978.01770320093009

• Research indicates that brain peptides exert both behavioral and endocrinologic effects in humans and animals. This review summarizes the best known behavioral actions of four endogenous peptides: luteinizing hormone-releasing hormone (LHRH), adrenocorticotrophic hormone (ACTH), vasopressin, and angiotensin. The hypothalamic-releasing hormones play a role in modulating pituitary-end organ systems. Behavioral disorders may, in the future, be susceptible to formulation in terms of changes in brain peptides. Peptide research in psychiatry may be approached in several ways.