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February 1979

HLA Antigens and Schizophrenia

Author Affiliations
From the Departments of Psychiatry (Dr Crowe and Ms Weinberger) and Medicine (Dr Thompson) and the Tissue Typing Laboratory (Mr Flink), University of Iowa College of Medicine, Iowa City.
Arch Gen Psychiatry. 1979;36(2):231-233. doi:10.1001/archpsyc.1979.01780020121014

• We typed 45 schizophrenic patients for 35 HLA antigens and compared their frequencies with 1,263 population controls. No significant differences between schizophrenics and controls were found. When the schizophrenics were subtyped, a significant (P <.05) excess of Aw26 was found among the hebephrenics, compared with the population controls. When the published literature on schizophrenia-HLA associations was surveyed, none of the reported associations were found to be consistent across studies. Some possible explanations for the heterogeneity among studies are discussed and it is concluded that an association between schizophrenia and any of the HLA antigens has not yet been demonstrated.