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February 1979

On βH-Leu5-Endorphin and Schizophrenia

Author Affiliations

From the Roche Institute of Molecular Biology, Nutley, NJ (Drs Lewis, Gerber, Stein, and Udenfriend); and the Departments of Psychiatry (Dr Grosser) and Biological Chemistry (Dr Velick), and the Bioengineering Division of Artificial Organs (Dr Stephen), University of Utah, Salt Lake City.

Arch Gen Psychiatry. 1979;36(2):237-239. doi:10.1001/archpsyc.1979.01780020127015

• A previously unknown peptide, βH-Leu5-endorphin, has been reported in the dialysates of schizophrenic patients. Accordingly, hemofiltrates from two schizophrenic and two control patients were examined for the presence of βH-Leu5-endorphin. The opioid peptides were detected by a radioreceptor assay after separation and identification by gel filtration and high-performance liquid chromatography. With a detection limit of 30 pmole/L of hemofiltrate, no βH-Leu5-endorphin or Met5-endorphin was found in controls or in patients. Whatever the possible involvement of endorphins in schizophrenic behavior, they are not present at detectable levels in the hemofiltrates of two wellcharacterized schizophrenic patients, thereby casting doubt on a general relationship of Leu-endorphin and schizophrenia.

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