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May 1979

Tardive Dyskinesia—Reversible and Persistent

Author Affiliations

From the Laboratory of Clinical Psychopharmacology, Division of Special Mental Health Research, Intramural Research Program, National Institute of Mental Health, St Elizabeth's Hospital, Washington, DC (Dr Jeste, Dr Potkin, and Dr Wyatt), and the New York Hospital and Cornell Medical Center, Westchester Division, White Plains (Dr Sinha and Dr Feder).

Arch Gen Psychiatry. 1979;36(5):585-590. doi:10.1001/archpsyc.1979.01780050095012

• Twenty-one hospitalized patients over 50 years of age who had tardive dyskinesia were studied for 13 months. After withdrawal of neuroleptics and antidepressants for three months, dyskinetic symptoms abated in 12 patients and persisted in nine. Discriminant function analysis showed that the persistent and reversible dyskinesia groups could be clearly separated and that the best discriminator was the number of drug-free intervals. The persistent dyskinesia group had had significantly longer neuroleptic treatment (mean, 10.8 yr) and a greater number (mean, 5.6) of drug interruptions of at least two months' duration each than did the reversible dyskinesia group. Our finding, as well as the literature reviewed, does not support the commonly held notion that frequent lengthy interruptions of long-term drug treatment reduce the incidence of persistent dyskinesia, at least in patients who are otherwise predisposed to the development of tardive dyskinesia.