Dr Dorus agreed with many of the conclusions of the Panel, but there seem to be two points of disagreement: (1) She conceptualized interaction strictly in terms of analysis of variance. (2) She maintained that since "gene-environment interactions play a more substantial role in psychiatric disorders, traditional genetic strategies... are not suitable." We would be most reluctant to limit the concept of interaction to the analysis of variance. It is curious that Dr Dorus cited Lewontin1 because his excellent article showed that a strict statistical interpretation of geneenvironment interaction is inadequate for an understanding of biological processes and etiology of disease. The interest of the Panel was not as much in the estimation of the components of variance as in the explication of the etiologic roles and biological interaction of specific genes and environmental factors. Thus, in the example given by Dr Dorus, it would be important to determine whether
Kidd KK, Matthysse S. Importance of Studying Gene-Environment Interactions Psychiatric Disorders-Reply. Arch Gen Psychiatry. 1979;36(6):720–721. doi:10.1001/archpsyc.1979.01780060110015
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: