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November 1979

Serum Calcium and Magnesium Levels in Schizophrenia: II. Possible Relationship to Extrapyramidal Symptoms

Author Affiliations

From the Section of Psychiatry and Human Behavior, Division of Biology and Medicine, Brown University; and the Intensive Treatment Unit, Butler Hospital, Providence, RI (Dr Alexander); and the Unit on Neuropsychopharmacology (Dr van Kammen), Biological Psychiatry Branch (Dr Bunney), National Institute of Mental Health, Bethesda, Md.

Arch Gen Psychiatry. 1979;36(12):1372-1377. doi:10.1001/archpsyc.1979.01780120102012

• The relationship between serum calcium and magnesium levels and neuroleptic-induced extrapyramidal symptoms (EPS) was studied in schizophrenic patients. The 16 patients in whom EPS developed had a significantly lower mean drug-free calcium level than the six patients in whom EPS did not develop. In patients in whom EPS developed, drug-free serum calcium and magnesium levels together correlated significantly with the neuroleptic dosage at which EPS first developed; lower calcium and magnesium values predicted EPS at lower dosages. We have previously shown that bom serum calcium and magnesium levels were significantly lower during neuroleptic treatment than in the drug-free state. In this study, a similar trend was observed, but the calcium value tended to be, and the magnesium value was significantly lower at the onset of neuroleptic-induced EPS than during the mean of an entire pimozide trial.

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