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March 1980

Dopamine βHydroxylase in CSF: Relationship to Personality Measures

Author Affiliations

From the National Institute of Mental Health (Drs Major, Lerner, Goodwin, Ballenger, and Brown), and the National Heart, Lung and Blood Institute (Dr Lovenberg), Bethesda, Md. Dr Major is now with the Department of Psychiatry, State University of New York at Binghamton.

Arch Gen Psychiatry. 1980;37(3):308-310. doi:10.1001/archpsyc.1980.01780160078009

• Dopamine β-hydroxylase (DBH), the enzyme that converts dopamine to norepinephrine, was measured in the CSF of 32 subjects. Those individuals with a low level of DBH in the CSF had significantly elevated profiles on the Minnesota Multiphasic Personality Inventory, suggesting a relationship between the central noradrenergic system and some aspects of personality in man.