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March 1980

Single-Dose Kinetics Predict Steady-State Concentrations of Imipramine and Desipramine

Author Affiliations

From the Clinical Psychobiology Branch (Drs Potter and Goodwin) and the Laboratory of Clinical Science (Dr Kopin), National Institute of Mental Health, and the Pharmacology/Toxicology Program, National Institute of General Medical Sciences (Dr. Zavadil), Bethesda, Md.

Arch Gen Psychiatry. 1980;37(3):314-320. doi:10.1001/archpsyc.1980.01780160084010

• Single-dose prediction of ultimate steady-state concentrations of tricyclic antidepressants at the outset of treatment can be a valuable therapeutic tool that has had only limited application. We demonstrate accurate steady-state predictions following both the tertiary amine, imipramine hydrochloride, and the secondary amine, desipramine hydrochloride, in a carefully monitored long-term treatment patient population. Results show that long-term treatment does not alter metabolism of either imipramine or desipramine. The relative merits of single-dose predictions using total and "abbreviated" areas under the curve and concentration at 24 hours are compared. These findings demonstrate that single-dose prediction can be used as a practical therapeutic, as well as, research tool.

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