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March 1980

Platelet Monoamine Oxidase Activity and Schizophrenia

Author Affiliations

Department of Psychiatry University of Chicago Pritzker School of Medicine 950 E 59th St Chicago, IL 60637 Illinois State Psychiatric Institute 1601 W Taylor St Chicago, IL 60612

Arch Gen Psychiatry. 1980;37(3):357. doi:10.1001/archpsyc.1980.01780160127015

To the Editor.—  Bond, Cundall, and Falloon1 recently reported that plate-let monoamine oxidase (MAO) activity in 15 newly admitted schizophrenics was not significantly different from that of 15 controls, but that those with auditory hallucinations (N = 4) had less MAO activity than those who did not (N = 11). Mann and Thomas2 also found no difference in platelet MAO activity between 55 schizophrenics and five controls but found no difference in platelet MAO activity between schizophrenics with definite hallucinations (N = 31) and those without hallucinations (N = 2). We calculated that the incidence of hallucinations in the two populations of schizophrenics was significantly different (X2 = 16.81, P <.001). This suggests that the two studies were based on different types of schizophrenic populations or different means of determining the presence or absence of hallucinations.Schildkraut et al3 and we4 reported that schizophrenics who hallucinated had significantly less platelet

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