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Article
October 1980

Aberrant Monoamine Metabolite Levels in CSF and Family History of Schizophrenia: Their Relationships in Schizophrenic Patients

Author Affiliations

From the Laboratory of Experimental Psychiatry, Department of Psychiatry, Karolinska Hospital, Stockholm (Dr Sedvall); and the Department of Psychiatry, St Göran's Hospital, Karolinska Institute, Stockholm (Dr Wode-Helgodt).

Arch Gen Psychiatry. 1980;37(10):1113-1116. doi:10.1001/archpsyc.1980.01780230031004
Abstract

• In 36 drug-free schizophrenic patients, lumbar CSF was analyzed by mass fragmentography for the major monoaminergic transmitter metabolites 5-hydroxyindoleacetic acid (5-HIAA), homovanillic acid (HVA), and 3-methoxy-4-hydroxyphenylglycol (MHPG). High or deviant concentrations of 5-HIAA were significantly related to a family history of schizophrenia. For patients with deviant 5-HIAA levels, the probability for a family history of schizophrenia was eight times higher than in subjects with normal values. High concentrations of HVA also tended to be significantly related to a family history of schizophrenia. The majority of schizophrenic patients, who lacked family history for the disorder, had normal monoamine metabolite concentrations in CSF. The results suggest a coupling between biochemical variables related to central serotonin and dopamine metabolism and forms of schizophrenia that have a familial disposition.

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