• We undertook a blind family history study of Briquet's syndrome to complement earlier follow-up work by Perley and Guze. The same criteria were used in a chart review to select 49 Briquet's syndrome cases. One control group consisted of consecutive "non-Briquet hysteria" admissions and another of matched primary unipolar depressed cases. First-degree relatives of the Briquet's syndrome probands had significantly less affective disorder and more "complicated medical history" then either control group. The "non-Briquet hysteria" group contained more family histories with instances of schizophrenia than either the Briquet's syndrome or affective disorder groups. These results provide additional validation of the Briquet's syndrome diagnosis.
Coryell W. A Blind Family History Study of Briquet's Syndrome: Further Validation of the Diagnosis. Arch Gen Psychiatry. 1980;37(11):1266–1269. doi:10.1001/archpsyc.1980.01780240064007
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