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December 1980

Familial Pattern of Gilles de la Tourette Syndrome

Author Affiliations

From the Departments of Human Genetics (Dr Kidd) and Psychiatry (Dr Prusoff) and the Child Study Center (Dr Cohen), Yale University School of Medicine, New Haven, Conn.

Arch Gen Psychiatry. 1980;37(12):1336-1339. doi:10.1001/archpsyc.1980.01780250022001

• As part of a pilot questionnaire survey of Gilles de la Tourette syndrome (TS), data on TS and tics for relatives of 75 patients with TS were collected. The frequencies of TS and/or tics among relatives were significantly heterogeneous in a familial pattern that suggests (1) that the disorder is transmitted, with tics alone being a milder manifestation, and that this severity difference is a threshold phenomenon related to transmission; (2) that the sex difference in prevalence is real because it was found among relatives of both male and female probands; and (3) that the sex difference is related to transmission as a threshold effect since female probands, although less common than male probands, had a higher proportion of affected relatives. These pilot data provide evidence for the transmission of TS and can be qualitatively explained by a genetic model of transmission.

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