This article is only available in the PDF format. Download the PDF to view the article, as well as its associated figures and tables.
Errors have been detected in the computer program used to analyze the data in the report entitled "Multiple Threshold Transmission of Affective Disorders" by Baron et al (Archives 1981;38:79-84). The statement that the data fit the single-major-locus hypothesis is therefore incorrect and, accordingly, conclusions based on that statement must be withdrawn. The errors detected do not invalidate the raw data. Although we lack statistical support, the raw data in our view may be interpreted as consistent with a genetic spectrum (or threshold) hypothesis whereby bipolar illness is more deviant genetically than unipolar disorder. The precise mode of transmission, however, cannot be specified.
Baron M. Computer Program Errors. Arch Gen Psychiatry. 1982;39(3):355. doi:10.1001/archpsyc.1982.04290030079014
* * SCHEDULED MAINTENANCE * *
The JAMA Network Sites will be conducting routine maintenance from 10/20/2017 through 10/21/2017. During this window access to content and authentication may be intermittently available. The JAMA Store will be completely unavailable during the maintenance window.