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— Dr Johnson and his colleagues have presented interesting data that support the idea that the increased severity of TD among older patients cannot be explained by their histories of longer neuroleptic treatment (although no data were presented on cumulative neuroleptic doses given equal durations). They were fortunate in that their older patients did not seem to have histories of significantly longer treatment with neuroleptics; in most epidemiologic studies this is not the case. Their findings and those of many other investigators strongly suggest that the increased prevalence and severity of TD in groups of older patients cannot be easily explained by their usually significantly longer exposure to neuroleptics. In fact, most epidemiologic studies find no significant relationship between TD and either cumulative length or dose of neuroleptics. Although the retrospective
Smith JM. Incidence and Severity of Tardive Dyskinesia Increase With Age-Reply. Arch Gen Psychiatry. 1982;39(4):486. doi:10.1001/archpsyc.1982.04290040080013