• We located 113 former inpatients with panic disorder 35 years after index admission. According to age-and sex-specific Iowa population figures, patients with panic disorder had significant excess mortality due to death by unnatural causes. Other studies suggest that secondary depression and alcoholism may have had a role in these deaths. Men with panic disorder also exhibited excess mortality due to circulatory system disease. In an age-and sex-matched patient group with primary unipolar depression, both men and women showed excess mortality. Suicide accounted for 20.0% and 16.2% of deaths in the panic disorder and primary depression groups, respectively. We conclude that panic disorder accounted for much of the excess mortality formerly noted in the "neuroses."
Coryell W, Noyes R, Clancy J. Excess Mortality in Panic DisorderA Comparison With Primary Unipolar Depression. Arch Gen Psychiatry. 1982;39(6):701–703. doi:10.1001/archpsyc.1982.04290060051010