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January 1983

Rapid Cycling-Reply

Arch Gen Psychiatry. 1983;40(1):108. doi:10.1001/archpsyc.1983.01790010114017

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In Reply.—  Dr Wehr's more parsimonious explanation is a valuable addition to my case report. However, previous attempts to wean the patient from tricyclic maintenance had resulted in unbearably painful depression. During a subsequent hospitalization for pneumonia, the patient's internist and I withdrew carbamazepine to evaluate any possible blood toxicity. Within a day, the patient complained of dysphoria and was becoming steadily more depressed. Carbamazepine therapy was resumed within the week, and the patient's mood improved.

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