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February 1983

Sleep Architecture and REM Sleep Measures in Prepubertal Major Depressives: Studies During Recovery From the Depressive Episode in a Drug-Free State

Author Affiliations

From the Department of Psychiatry, College of Physicians and Surgeons, Columbia University, and the New York State Psychiatric Institute, New York (Dr Puig-Antich, Mr Goetz, Mss Hanlon and Tabrizi, and Mr Davies); and the Laboratory of Human Chronophysiology, Department of Neurology, Albert Einstein College of Medicine, and Montefiore Hospital and Medical Center, Bronx, NY (Dr Weitzman).

Arch Gen Psychiatry. 1983;40(2):187-192. doi:10.1001/archpsyc.1983.01790020085008

• The sleep of 28 fully recovered, drug-free, prepubertal patients with major depressive disorder was recorded for three consecutive nights in the laboratory. Recovered depressives had significantly shorter first rapid eye movement period (REMP) latencies and a higher number of REMPs compared with themselves when depressed and with nondepressed neurotic and normal children. In addition, most sleep continuity measures improved considerably on recovery. We suggest that a short first REMP latency may be a marker of past episode or of trait in prepubertal major depressives.