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March 1983

Study of Gluten Effect in Schizophrenia-Reply

Author Affiliations

Jamie M. Clopton, MS Charees Wright Psychology Service (116B) Veterans Administration Medical Center 3350 La Jolla Village Dr San Diego, CA 92161

Arch Gen Psychiatry. 1983;40(3):346. doi:10.1001/archpsyc.1983.01790030116018

In Reply.—  Drs Singh and Kay suggested that our study on the effects of gluten on schizophrenics was "scientifically weak." They state that because of a high risk of type II error and insufficient time for the gluten-free diet to work, the study might have failed to pick up "weak effects."We are under no illusions that we confirmed the null hypothesis. Our report stated that because of our small number of subjects, we did not eliminate the possibility that a gluten-free diet is helpful for subgroups of schizophrenics, as Singh and Kay suggested earlier.1 We also said that eliminating gluten for a longer period, as Singh and Kay did in their study, might be effective.Also, our study was an attempt to confirm previous results,1,2 which were not "weak effects" of gluten-free diets but fairly strong effects. Our design was similar to that of Dohan et al,2 and the length of time that

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