To the Editor—
The article "Regional Cerebral Blood Flow in Schizophrenia" by Mathew et al (Archives 1982;39:1121-1124) deals with one of the major interfaces between the study of cerebral circulation and psychiatric conditions, and constitutes an important contribution to the field. Therefore, it is regretable that we must point out major problems and ambiguities in this work.A previous article by Mathew et al1 was criticized on the issue of inappropriate control comparisons.2 Their recent study used the same between-group design and unfortunately can be criticized on the same grounds. In such designs, the nature of the control group determines to a large extent the validity of any conclusion. The only information provided by Mathew et al about their controls was that they did not meet DSM-III criteria for schizophrenia, and were matched for age, sex, and handedness. Readers were not informed whether the controls were patients
Prohovnik I, Sackeim HA, Malitz S, Decina P. Cerebral Blood Flow in Schizophrenia. Arch Gen Psychiatry. 1983;40(7):811. doi:10.1001/archpsyc.1983.01790060109014
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