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July 1983

Cerebral Blood Flow in Schizophrenia-Reply

Author Affiliations

Department of Psychiatry Vanderbilt University School of Medicine Nashville, TN 37232

Arch Gen Psychiatry. 1983;40(7):811-812. doi:10.1001/archpsyc.1983.01790060109015

In Reply.—  The first criticism of our study made by Prohovnik et al is that control comparisons are inappropriate because between-group comparisons were used and details of the screening for psychopathologic disorders in the controls were not given. If the authors had carefully read the article by Gustafson et al cited to substantiate their point, they would have noticed that the report is based on between-group comparisons of patients with dementias and depression, and normal subjects. Details of the method for excluding psychiatric illnesses (only chronic psychoses and addictions were excluded) in the normal subjects were not given and the groups were not matched for age, sex, or cerebral dominance (mean age: controls, 28 ± 7 years; depressed subjects, 60 ± 14 years). Prohovnik et al also made between-group comparisons of the CBF values of our patients (N = 23; age, 26.9 ± 8.9 years) with the normal values published by Meyer et