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August 1983

Low-Dose Neuroleptic Treatment of Outpatient Schizophrenics: I. Preliminary Results for Relapse Rates

Author Affiliations

From the Long Island Jewish—Hillside Medical Center, Glen Oaks, NY (Drs Kane, Woerner, Sarantakos, and Ramos-Lorenzi), and the Mt Sinai Medical Center, New York (Drs Rifkin and Schiebel and Mr Reardon).

Arch Gen Psychiatry. 1983;40(8):893-896. doi:10.1001/archpsyc.1983.01790070083010

• In an attempt to begin to establish minimum effective dosage requirements for the maintenance treatment of schizophrenia, we undertook a double-blind comparison of low-dose fluphenazine decanoate (1.25 to 5.0 mg/2 wk) with the standard-dose regimen (12.5 to 50.0 mg/2 wk) in outpatient schizophrenics. For the first 126 patients studied, cumulative relapse rates at one year for the low dose were 56% and for the standard dose 7%, a significant difference. Despite the fact that very little dyskinetic symptomatology developed in the sample as a whole, the low-dose treatment appeared to have a significant advantage in producing fewer early signs of tardive dyskinesia. Severity of relapse and total cumulative dosage were also considered.

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