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April 1984

Social and Environmental Influences on Blood Serotonin Concentrations in Monkeys

Author Affiliations

From the Department of Psychiatry and Biobehavioral Sciences, UCLA School of Medicine; the Nonhuman Primate Research Center, Veterans Administration Medical Center, Sepulveda, Calif (Drs Raleigh, McGuire, and Brammer); and the Neurobiochemistry Laboratory, Brentwood Veterans Administration Medical Center, Los Angeles (Drs Raleigh, Brammer, and Yuwiler).

Arch Gen Psychiatry. 1984;41(4):405-410. doi:10.1001/archpsyc.1984.01790150095013

Dominant male adult vervet monkeys have whole-blood serotonin concentrations approximately twice those of subordinate adult males. We examined the effects of spontaneous and induced changes In social status, temporary isolation from the social group, and membership in single male groups on whole-blood serotonin concentrations. We found that in male vervet monkeys, elevated blood serotonin concentration is a state-dependent consequence of active occupation of the dominant male social position, and we believe that a reinterpretation of the significance of hyperserotonemia in humans may be warranted.