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May 1984

Growth Hormone Secretion in Prepubertal Children With Major Depression: I. Final Report on Response to Insulin-Induced Hypoglycemia During a Depressive Episode

Author Affiliations

From the Department of Child Psychiatry (Drs Puig-Antich, Chambers, and Ambrosini and Ms Tabrizi), the Sleep/Neuroendocrine Unit, New York State Psychiatric Institute (Drs Puig-Antich and Sachar, Mss Novacenko and Krawiec, and Mr Davies), and the Department of Psychiatry, Columbia University, College of Physicians and Surgeons (Drs Puig-Antich, Chambers, Ambrosini, and Sachar), New York.

Arch Gen Psychiatry. 1984;41(5):455-460. doi:10.1001/archpsyc.1984.01790160041004

• Insulin tolerance tests (ITTs) were carried out on 46 drugfree prepubertal children with severe emotional disorders. Thirteen met unmodified Research Diagnostic Criteria for major depressive disorder, definite endogenous subtype, 17 met the criteria for nonendogenous major depressive disorder, and 16 fit DSM-III criteria for nondepressed neurotic disorders. The group with endogenous depression had significant hyposecretion of growth hormone (GH) in this test when compared with the other groups. Since GH hyposecretion in response to ITT has been found in most studies to be associated with endogenous major depression in adults, the data support the validity of the diagnosis of prepubertal endogenous major depressive disorder and the hypothesis of similarity or identity of prepubertal and adult major depressive disorders.

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