• A post hoc analysis of the relationship between depression in first-degree family members (N=810) and specific patterns of "endogenous" symptoms in 133 probands with nonbipolar major depression revealed that concomitant appetite disturbance and excessive guilt in the depressed probands was associated with increased rates of major depression among family members. The depressed, interviewed relatives of depressed probands with appetite disturbance and excessive guilt were found to be at a 2.5 greater risk for this same subtype compared with the depressed, interviewed relatives of the remaining depressed probands. These findings suggest that this subtype of depression may "breed true" within these families.
Leckman JF, Caruso KA, Prusoff BA, Weissman MM, Merikangas KR, Pauls DL. Appetite Disturbance and Excessive Guilt in Major DepressionUse of Family Study Data to Define Depressive Subtypes. Arch Gen Psychiatry. 1984;41(9):839–844. doi:10.1001/archpsyc.1984.01790200021003