Zimmerman and Coryell stated that our DST results in normal subjects are in marked contrast to those reported in the literature. Though Zimmerman and Coryell apparently raised only a question of differences in frequency of DST nonsuppression in normal subjects, this is in fact not a simple issue. The DST response is of intense research and possible clinical interest and it is important to understand that it is modified by many factors. Therefore, it is worth the time and effort to examine carefully our data, important factors influencing DST response, and the data cited by Zimmerman and Coryell. The Table lists by age group the nonsuppression frequency we observed in our 62 healthy control subjects with three post-DST plasma cortisol samples. Nonsuppression was most frequent in the 35- to 64-year-old age group. The mean age ( ± SD) of our healthy control subjects was 46 ±15 years (47 ±14 in depressed
Stokes PE, Stoll PM, Koslow SH, et al. Limited Utility of the 1-mg Dexamethasone Suppression Test as a Measure of Hypercortisolism-Reply. Arch Gen Psychiatry. 1985;42(2):202–204. doi:10.1001/archpsyc.1985.01790250096014
Psychiatry in JAMA: Read the Latest
Customize your JAMA Network experience by selecting one or more topics from the list below.