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March 1985

Atrophy Limited to the Third Ventricle in Chronic Schizophrenic Patients: Report of a Controlled Series

Author Affiliations

From the Sheppard-Pratt Hospital, Towson, Md (Dr Boronow); the Clinical Neuroscience Branch, National Institute of Mental Health, Bethesda, Md (Drs Pickar, Roy, Hommer, and Paul); Emory University Clinic, Atlanta (Dr Ninan); and the National Institute on Alcohol Abuse and Alcoholism, Bethesda, Md (Dr Linnoila).

Arch Gen Psychiatry. 1985;42(3):266-271. doi:10.1001/archpsyc.1985.01790260060007

• Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, thirdventricle diameter, and cerebellar atrophy. Schizophrenic tients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.

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