• Computed tomographic scans of 30 chronic schizophrenic patients and 26 matched medical controls were blindly assessed for ventricular brain ratio, cortical atrophy, thirdventricle diameter, and cerebellar atrophy. Schizophrenic tients had significantly larger third ventricles than the medical controls. There was no difference in the other brain morphologic variables. Phenomenology, drug response, CSF levels of 5-hydroxyindoleacetic acid, 3-methoxy-4-hydroxyphenylglycol, homovanillic acid, and a wide variety of clinical variables did not correlate with any measure of brain morphology. Clinicopathologic correlates of brain morphology may be limited to those patients with significant atrophy.
Boronow J, Pickar D, Ninan PT, et al. Atrophy Limited to the Third Ventricle in Chronic Schizophrenic Patients: Report of a Controlled Series. Arch Gen Psychiatry. 1985;42(3):266–271. doi:10.1001/archpsyc.1985.01790260060007
Artificial Intelligence Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.