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April 1985

Pharmacologic Evidence for Specificity of Pursuit Dysfunction to Schizophrenia: Lithium Carbonate Associated With Abnormal Pursuit

Author Affiliations

From the Departments of Psychiatry (Drs Levy, Dorus, and Shaughnessy) and Radiology (Mr Yasillo), University of Chicago; the Department of Psychiatry, University of Illinois, Chicago (Drs Pandey, Janicak, Gibbons, Gaviria, and Davis); and the Department of Research, Illinois State Psychiatric Institute, Chicago (Drs Levy, Pandey, Janicak, and Davis).

Arch Gen Psychiatry. 1985;42(4):335-341. doi:10.1001/archpsyc.1985.01790270021002

• Conflicting findings regarding the prevalence of abnormal smooth-pursuit eye movements in patients with major affective disorders call into question the specificity of impaired smooth-pursuit eye movements to schizophrenia. We report that pursuit is impaired in 88% of lithium carbonate—treated affective disorder patients whose pursuit was normal prior to receiving this drug. Over half of lithium carbonate—treated affective disorder patients in remission also showed impairment of smooth-pursuit eye movements. In conjunction with recent prevalence data on family members of psychiatric patients, the findings support the specificity of abnormal pursuit as a biological trait associated with schizophrenia, but not with the major affective disorders. The mechanisms by which lithium carbonate impairs pursuit are discussed.

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