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August 1985

Electroencephalographic Sleep of Younger Depressives: Comparison With Normals

Author Affiliations

From the Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine (Drs Kupfer, Jarrett, and Grochocinski, Messrs Ulrich, Doman, and Matthews, and Ms Coble); and the Pharmakologisches Institut der Universitat Zurich (Dr Borbély).

Arch Gen Psychiatry. 1985;42(8):806-810. doi:10.1001/archpsyc.1985.01790310068009

• The electroencephalographic sleep of younger depressives (aged 20 to 44 years) was compared with that of an age-matched group of normals. The patients demonstrated many of the typical sleep changes reported for older depressed populations: shortened rapid-eye-movement (REM) latency; REM sleep activity alterations, with a shift to the early portion of the night (first REM period); reduced delta sleep; and sleep efficiency reductions marked by sleep-onset difficulties. The traditional scoring procedures were supplemented by automated REM and delta-sleep analyses that provided more precise delineation of these differences between patients and normals, particularly the distributions of REM activity and delta-wave patterning.