• Cerebrospinal fluid (CSF) and plasma 3-methoxy-4-hydroxyphenylglycol (MHPG) concentrations were significantly elevated in patients during the alcohol withdrawal syndrome. When CSF MHPG was corrected using a formula proposed to determine CSF MHPG levels of central origin, these values were still significantly elevated when compared with control values. The MHPG concentrations in CSF also showed significant positive correlations with heart rate, systolic and diastolic blood pressures, tremor, anorexia, and sweating. The results of this study indicate increased presynaptic release of norepinephrine during alcohol withdrawal.
Hawley RJ, Major LF, Schulman EA, Linnoila M. Cerebrospinal Fluid 3-Methoxy-4-hydroxyphenylglycol and Norepinephrine Levels in Alcohol Withdrawal: Correlations With Clinical Signs. Arch Gen Psychiatry. 1985;42(11):1056–1062. doi:10.1001/archpsyc.1985.01790340034005
Browse and subscribe to JAMA Network podcasts!
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: