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February 1986

Cerebral Ventricular Enlargement in Schizophrenia: A Preliminary Follow-up Study

Author Affiliations

From the Veterans Administration Medical Center (Dr Nasrallah and Ms Chapman), and the Departments of Psychiatry (Drs Nasrallah and Olson and Ms McCalley-Whitters) and Radiology (Dr Jacoby), University of Iowa College of Medicine, Iowa City. Drs Nasrallah and Olson are now with the Department of Psychiatry, The Ohio State University, Columbus.

Arch Gen Psychiatry. 1986;43(2):157-159. doi:10.1001/archpsyc.1986.01800020067008

• Lateral cerebral ventricular enlargement is now known to occur in some schizophrenic patients. To determine whether ventriculomegaly in schizophrenia is a static vs progressive process, we conducted a follow-up computed tomographic brain scan study on 11 young male patients, three years after initial scans were obtained. No significant change was found in the mean ventricles-brain ratio of this small schizophrenic sample after three years. Four of 11 patients showed noticeable increases (>50%) in individual ratio. Methodologic problems are discussed and the need for follow-up studies as a research strategy is emphasized.

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