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January 1987

Efficacy of Imipramine and Chlordiazepoxide in Depressive and Anxiety Disorders Questioned-Reply

Author Affiliations

Boston University Clinical Psychopharmacology Laboratory 270 Babcock St Boston, MA 02215
Friends Hospital Roosevelt Boulevard and Adams Avenue Philadelphia, PA 19124

Arch Gen Psychiatry. 1987;44(1):97-98. doi:10.1001/archpsyc.1987.01800130109022

Reply.—  Concerning the depressed cases, it should be stressed that 75% of the depressed sample met DSM-III criteria for a major depressive disorder and that all patients were required to be moderately depressed, as indexed by a score of at least 8 on the Raskin Depression Scale. In their inpatient studies, Raskin et al1 employed a score of 9 on this screen, while outpatient studies by Klerman and his colleagues2 used a score of 7. Moreover, as we pointed out in the above-referenced article (page 71), two of the 21 items of the New Clinical Drug Evaluation Units version of the Hamilton Depression Scale were not scored. Further, all patients were judged by experienced psychiatrists to be in need of pharmacologic treatment. In short, this is a bona fide clinically depressed sample.While we do not know why these patients did not show as much improvement in their clinical

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