To the Editor.—
The recent report of an MRI study of the brains of schizophrenic patients compared with normal controls1 is of interest to us. Dr Andreasen and colleagues propose, on the basis of measurements performed on a midsagittal brain image, that schizophrenic men have smaller brains and craniums than normal men. They further suggest that this is consistent with an early developmental dysplastic process.To explore this proposal further, we reexamined our CT data that were reported in the same issue of the ARCHIVES.2 Total brain circumference from two CT slices that visualize the lateral ventricles were used for comparisons. Heights of all individuals were obtained. Total brain area was significantly smaller in the schizophrenic patients (N = 26) compared with controls (N = 20) for the slice maximally visualizing the lateral ventricles (t = 2.05, P =.05), but not different from controls for the slice taken through the maximal area of the
DeLisi LE, Goldin LR. Hat Size in Schizophrenia. Arch Gen Psychiatry. 1987;44(7):672–673. doi:10.1001/archpsyc.1987.01800190092015
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