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October 1987

Tardive Dyskinesia and Steady-State Serum Levels of Thiothixene

Author Affiliations

From the Department of Psychiatry and Behavioral Sciences, Stanford (Calif) University School of Medicine; and Palo Alto (Calif) Veterans Administration Medical Center.

Arch Gen Psychiatry. 1987;44(10):913-915. doi:10.1001/archpsyc.1987.01800220085012

• The purpose of this investigation was to determine the relationship between serum levels of the neuroleptic agent thiothixene and tardive dyskinesia in schizophrenics of a wide age range. Forty-one male schizophrenic subjects, 21 with tardive dyskinesia and 20 without, were given a fixed dosage of thiothixene hydrochloride (10 mg orally four times daily) after a drug-free period of one week. Higher steady-state serum levels of thiothixene (obtained after five days of a fixed-dosage schedule) were associated with greater degrees of tardive dyskinesia. This relationship was independent of the relationship between tardive dyskinesia and age.

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