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June 1988

Plasma Homovanillic Acid as a Predictor of Response to Neuroleptics

Author Affiliations

From the Centro de Investigacion Neuroquimica, Osakidetza Gobierno Vasco, Zamudio, Spain (Drs Davila and Manero and Mss Zumarraga and Andia); and the Millhauser Laboratories, Department of Psychiatry, New York University School of Medicine (Drs Schweitzer and Friedhoff).

Arch Gen Psychiatry. 1988;45(6):564-567. doi:10.1001/archpsyc.1988.01800300060007

• Fourteen schizophrenic subjects were evaluated for degree of psychosis before and after treatment with the antipsychotic drug haloperidol and for plasma homovanillic acid concentration after four and 28 days of treatment. A significant correlation was found between an increase in homovanillic acid concentration on day 4 or a decrease from day 4 to day 28 and the degree of improvement after four weeks of treatment. Thus, those patients who had the greatest change in plasma homovanillic acid in response to neuroleptic blockade showed the greatest improvement. These and other observations have led us to propose that the central dopaminergic system, through adaptive changes in activity, serves as a physiologic buffer system protecting against destabilization of mental function from diverse biologic or psychologic insults.

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